Ultrasonic Ketamine Uncaging for Non-Opioid Therapy of Chronic Pain

The next study is a wild one. They have used Focused Ultrasound (tFUS) to unlock an engineered molecular cage carrying a small-molecule drug so that the drug is only released in a precise region of the brain (to millimeter-scale). This can verify the mechanism of action in that particular brain region while avoiding systemic exposure and its side effects. They have shown this to work in animal models, delivering higher doses than systemic ketamine administration, and just to the targeted brain region. See charts below.

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Taken on: February 11, 2024

Tags:

Stanford

Neuro

Ultrasonic

Ketamine

Uncaging

for

Non-Opioid

Therapy

Chronic

Pain

Brain

stimulation

Lab

Psychedelic

Medicine « less

Sets appears in: • Weird Science • The Brain more » • Nano & Na not • Exploring Stanford « less

Camera: Apple iPhone 14 Pro Max, f/2.8, 1/41 sec, 9mm, ISO 500 (more info) (hide info)

Camera:	Apple iPhone 14 Pro Max
Aperture:	f/2.8
Exposure Time:	0.024 sec (1/41)
Focal Length:	9mm
ISO:	500
Exposure Bias:	0 EV
Flash:	Off, Did not fire
Exposure Program:	Program AE
Exposure Mode:	Auto
Metering Mode:	Spot
White Balance:	Auto
Color Space:	Uncalibrated
Software:	17.3.1
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